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The American Food and Drug Administration (FDA) has approved Orlistat for use as an over-the-counter weight loss drug for adults who are overweight. The drug, which was originally approved for Sep 18, 2020 · This article contains a list of 16 best supplements for weight loss that work instantly. 16 Best Weight Loss Supplements That Work . 1. Orlistat . Orlistat blocks the fat contained in what you eat by preventing the breakdown of fat in the gut. As a result, this keeps fat from being absorbed by your body. Some people call this pill Alli or Xenical.