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From healthy diet plans to helpful weight loss tools, here you'll find WebMD's latest diet news and information. The weight loss in the treatment group was modest, and the trial was only eight weeks, which isn't long enough to know if the supplement will help with weight loss long term. Plus, the supplement included multiple ingredients, making it impossible to judge which ingredients helped the weight loss. 7 Supplements To Consider for Weight Loss 1. Caffeine or Green Tea/Extract (Matcha) This is one of the quickest and most easily accessible supplements for weight loss. Caffeine can boost the metabolic rate and increase fat burning. However, people become tolerant to the effects, and as such its impact will slowly diminish.